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Me Region is a part of BIOS bin file. Usually bios bin file consist of OEM Region, Flash Descryptor, Bios Region, and Me Region. When you program a bios bin file to the BIOS IC using a programmer and you do not clean the bios with Me Region thats what we called a dirty BIOS, which can cause different problem to the laptop For example Laptop shuts down at a fix amount of time e.g. 30 minutes not one second up nor down then you have an ME Region issue.